Publications of Uris Ros

Ros, U.; Martinez-Osorio, V.; Valiente, P. A.; Abdelwahab, Y.; Gojkovic, M.; Shalaby, R.; Zanna, S.; Saggau, J.; Wachsmuth, L.; Nemade, H. N. et al.; Zoeller, J.; Lottermoser, H.; Chen, Y.-G.; Ibrahim, M.; Kelepouras, K.; Vasilikos, L.; Bedoya, P.; Espiritu, R. A.; Müller, S.; Altmannova, V.; Tieleman, D. P.; Weir, J.; Langer, J. D.; Adam, M.; Walczak, H.; Wong, W. W.-L.; Liccardi, G.; Mollenhauer, M.; Pasparakis, M.; Peltzer, N.; García-Sáez, A. J.: MLKL activity requires a splicing-regulated, druggable intramolecular interaction. Molecular Cell 85 (2025)

Schreier, S.; Paulino, J.; Carretero, G. P. B.; Barbosa, L. R. S.; Cilli, E. M.; Alvarez, C.; Ros, U.: Extension of sticholysins N-terminal α-helix signals membrane lipids to acquire curvature for toroidal pore formation. Biochemical and Biophysical Research Communications 742, 151071 (2025)

Rivero-Hernández, A. L.; Hervis, Y. P.; Valdés-Tresanco, M. E.; Escalona-Rodríguez, F. A.; Cancelliere, R.; Relova-Hernández, E.; Romero-Hernández, G.; Pérez-Rivera, E.; Torres-Palacios, Y.; Cartaya-Quintero, P. et al.; Ros, U.; Porchetta, A.; Micheli, L.; Fernández, L. E.; Laborde, R.; Álvarez, C.; Sagan, S.; Lanio, M. E.; Pazos Santos, I. F.: Decoupling immunomodulatory properties from lipid binding in the α-pore-forming toxin Sticholysin II. International Journal of Biological Macromolecules 280 (Pt 4), 136244 (2024)

Pedrera, L.; Ros, U.; García-Sáez, A. J.: Calcium as a master regulator of ferroptosis and other types of regulated necrosis. Cell Calcium 114, 102778 (2023)

Martinez-Osorio, V.; Abdelwahab, Y.; Ros, U.: The Many Faces of MLKL, the Executor of Necroptosis. International Journal of Molecular Sciences 24 (12), 10108 (2023)

Pedrera, L.; Ros, U.; Fanani, M. L.; Lanio, M. E.; Epand, R. M.; Garcia-Saez, A. J.; Álvarez, C.: The Important Role of Membrane Fluidity on the Lytic Mechanism of the α-Pore-Forming Toxin Sticholysin I. toxins 15, 80 (2023)

Wang, X.; Ros, U.; Agrawal, D.; Keller, E. C.; Slotta-Huspenina, J.; Dill, V.; Shen, B.; Shi, R.; Herold, T.; Belka, C. et al.; Mishra, R.; Bassermann, F.; Garcia Saez, A. J.; Jost, P. J.: MLKL promotes cellular differentiation in myeloid leukemia by facilitating the release of G-CSF. Cell Death and Differentiation 28, pp. 3235 - 3250 (2022)

Danial, J. S. H.; Quintana, Y.; Ros, U.; Shalaby, R.; Margheritis, E. G.; Chumpen Ramirez, S.; Ungermann, C.; Garcia-Saez, A. J.; Cosentino, K.: Systematic Assessment of the Accuracy of Subunit Counting in Biomolecular Complexes Using Automated Single-Molecule Brightness Analysis. The Journal of Physical Chemistry Letters 13 (3), pp. 822 - 829 (2022)

Cosentino, K.; Hermann, E.; von Kügelgen, N.; Unsay, J. D.; Ros, U.; García-Sáez, A. J.: Force Mapping Study of Actinoporin Effect in Membranes Presenting Phase Domains. Toxins 13 (9), 669 (2021)

Alvarez, C.; Soto, C.; Cabezas, S.; Alvarado-Mesén, J.; Laborde, R.; Pazos, F.; Ros, U.; Hernández, A. M.; Lanio, M. E.: Panorama of the Intracellular Molecular Concert Orchestrated by Actinoporins, Pore-Forming Toxins from Sea Anemones. Toxins 13 (8), 567 (2021)

Ros, U.; Pedrera, L.; Garcia-Saez, A. J.: Techniques for studying membrane pores. Current Opinion in Structural Biology 69, pp. 108 - 116 (2021)

Pedrera, L.; Espiritu, R. A.; Ros, U.; Weber, J.; Schmitt, A.; Stroh, J.; Hailfinger, S.; von Karstedt, S.; García-Sáez, A. J.: Ferroptotic pores induce Ca²⁺ fluxes and ESCRT-III activation to modulate cell death kinetics. Cell Death and Differentiation 28 (5), pp. 1644 - 1657 (2021)

Mesa-Galloso, H.; Pedrera, L.; Ros, U.: Pore-forming proteins: From defense factors to endogenous executors of cell death. Chemistry and Physics of Lipids 234, 105026 (2021)

Flores‐Romero, H.; Ros, U.; Garcia-Saez, A. J.: Pore formation in regulated cell death. The EMBO Journal 39 (23), e105753 (2020)

Ros Quincoces, U. L.; Pedrera, L.; Garcia Saez, A. J.: Partners in Crime: The Interplay of Proteins and Membranes in Regulated Necrosis. International Journal of Molecular Sciences 21 (7), 2412 (2020)

Mesa-Galloso, H.; Valiente, P. A.; Valdés-Tresanco, M. E.; Epand, R. F.; Lanio, M. E.; Epand, R. M.; Alvarez, C.; Tieleman, D. P.; Ros, U.; Ros, U.: Membrane Remodeling by the Lytic Fragment of SticholysinII: Implications for the Toroidal Pore Model. Biophysical Journal 117 (9), pp. 1563 - 1576 (2019)

Dimou, E.; Cosentino, K.; Platonova, E.; Ros, U.; Sadeghi, M.; Kashyap, P.; Katsinelos, T.; Wegehingel, S.; Noé, F.; García-Sáez, A. J. et al.; Ewers, H.; Nickel, W.: Single event visualization of unconventional secretion of FGF2. Journal of Cell Biology 218 (2), pp. 683 - 699 (2019)

Ros, U.; Carretero, G. P. B.; Paulino, J.; Crusca, E.; Pazos, F.; Cilli, E. M.; Lanio, M. E.; Schreier, S.; Alvarez, C.: Self-association and folding in membrane determine the mode of action of peptides from the lytic segment of sticholysins. Biochimie 156, pp. 109 - 117 (2019)

Soto, C.; Bergado, G.; Blanco, R.; Griñán, T.; Rodríguez, H.; Ros, U.; Pazos, F.; Lanio, M. E.; Hernández, A. M.; Álvarez, C.: Sticholysin II-mediated cytotoxicity involves the activation of regulated intracellular responses that anticipates cell death. Biochimie 148, pp. 18 - 35 (2018)

Lima de Oliveira, A.; Maffud Cilli, E.; Ros, U.; Crusca, E.; Lanio, M. E.; Alvarez, C.; Schreier, S.; Aguiar Pertinhez, T.; Spisni, A.: Insights on the structure-activity relationship of peptides derived from Sticholysin II. Peptide Science 110 (5) (2018)